BRCA Risks

Prevalence

• 1 in 400 in non-Jewish populations

• Ashkenazi Jewish = 1 in 40

Breast Cancer in Women

• BRCA1 carrier = lifetime risk of 57 to 72%

• BRCA2 carrier = 45 and 69%

Breast Cancer in Men

• Background risk = 1 in 1000 = 0.1%

• BRCA2 = lifetime risk is 1 in 25 = 4%

• BRCA1 = 1 in 250 = 0.4%

Ovarian Cancer

• BRCA1 = 39 to 59%

• BRCA2 = 11 to 20%

Fallopian Tube

• BRCA1/2 = 0.6%

• Background risk = 0.2%

Primary Peritoneal

• BRCA1/2 = 1.3%

• Background risk = Not known

Endometrial

• BRCA1/2 = Small increased risk but conflicting data

Pancreas

• BRCA1 = 1 to 3%

• BRCA2 = 2 to 5%

Prostate

• BRCA2 = Increase risk by 5 to 9 times

Colorectal

• Data inconsistent

Melanoma

• BRCA2 associated with melanoma but risk not well characterised

• BRCA1 = No clear association

• BRCA2 = increase risk of uveal melanoma

Stomach / Biliary

• BRCA2 = Lifetime risk = 3.5%

• In Japan - BRCA1/2 showed risk up to 20%

Resources:

• BRCA risk - Up To Date