MASLD

Fact sheet

• Fatty Liver

Terms

• NAFLD

  • <20g alcohol per day for women

  • <30g for men

• MAFLD

  • Overweight

  • T2DM

  • 2 x Metabolic risk factors

• MASLD

  • Fatty liver PLUS 1/5 of

    • Overweight+

    • Pre-diabetes+

    • HTN

    • Trig ^

    • Low HDL

  • Alcohol <20 or 30g

Mild MASLD

• 25% progress to NASH

• 30% to cirrhosis

• 50% to liver failure

• 5% to HCC

Prevalence

• MASLD = 25%

• T2DM risk up to 40%

• BMI > 40 = 45% risk

• Australian prevalence = 37%

When to suspect

• Hypobetalipoproteinemia

• LAL deficiency

• Nutrient deficiency

• Wilson disease

• Coeliac disease

• Drugs (MTX, Amiodarone, 5-FU, Irinotecan, Tamoxifen)

• Alcohol