Beta blockers
Medicines that slow the heart and blunt adrenaline. Used for heart conditions, blood pressure, migraine prevention and tremor. A whole family, each with its own personality.
Quick answer: Common beta blockers include metoprolol, bisoprolol, atenolol, propranolol, carvedilol, nebivolol, sotalol and labetalol; every generic name ends in “-lol”. They slow the heart and are used for heart conditions, blood pressure, migraine prevention and tremor. Common side effects are tiredness, cold hands and feet, and a slow pulse. Never stop them suddenly.
At a glance
- For
- Angina, after a heart attack, heart failure, atrial fibrillation, migraine prevention, tremor, blood pressure
- Works
- Heart failure: the right ones cut the risk of dying by about a third. Migraine: propranolol roughly halves attacks for many people
- Cost
- Most are under the $25 PBS co-payment, about $15–25 a script; $7.70 concession
- Kicks in
- Pulse slows within hours; migraine benefit takes 4–8 weeks
- Taken for
- Usually long term
- Watch for
- Tiredness, cold hands and feet, slow pulse, dizziness, vivid dreams or poor sleep
Cold hands and a slower pulse are part of the deal. Stopping cold turkey is not.
Brand names
- Metoprolol (Betaloc, Lopresor, Minax), atenolol (Noten, Tenormin)
- Bisoprolol (Bicor), carvedilol (Dilatrend), nebivolol (Nebilet)
- Propranolol (Deralin, Inderal), sotalol (Sotacor), timolol eye drops, many generics
List of beta blockers
Every generic name ends in “-lol”. Not all are sold in every country; brand names for the common Australian ones are listed above.
Heart-selective (mainly beta-1)
- Atenolol
- Bisoprolol
- Metoprolol
- Nebivolol
- Acebutolol
- Betaxolol (mainly as eye drops)
- Esmolol (hospital drip only)
Non-selective (beta-1 and beta-2)
- Propranolol
- Sotalol
- Nadolol
- Pindolol
- Oxprenolol
- Timolol (mainly as eye drops)
Also block alpha receptors (widen blood vessels)
- Carvedilol
- Labetalol (often used for high blood pressure in pregnancy)
How it works
They block the beta receptors that adrenaline acts on, so the heart beats slower and less forcefully and needs less oxygen. Blood pressure falls too.
Used for
- Angina, and after a heart attack
- Heart failure (bisoprolol, carvedilol, metoprolol slow-release, nebivolol)
- Heart rate control in atrial fibrillation and other fast rhythms
- High blood pressure (now rarely first choice)
- Preventing migraine; tremor (propranolol)
- Performance anxiety (propranolol; off-label); glaucoma (eye drops)
Compared
“Heart-selective” ones mainly block the beta-1 receptors in the heart, so they’re less likely to tighten the airways. “Non-selective” ones also block beta-2 receptors in the lungs and blood vessels.
- Heart-selectiveMetoprolol (Betaloc, Lopresor, Minax)
- Type
- Heart-selective
- Main uses
- Angina, after a heart attack, heart rate control, blood pressure; slow-release form for heart failure
- Good to know
- Ordinary tablets are usually taken twice a day. For heart failure, the proof is for the slow-release (succinate) form
- Very heart-selectiveBisoprolol (Bicor)
- Type
- Very heart-selective (less so at high doses)
- Main uses
- Heart failure (its approved use in Australia); also widely used for angina, heart rate control and blood pressure
- Good to know
- Once a day. In the CIBIS-II heart failure trial, 12% died versus 17% on a dummy treatment
- Heart-selectiveAtenolol (Noten, Tenormin)
- Type
- Heart-selective; less gets into the brain
- Main uses
- Blood pressure, angina, fast heart rhythms
- Good to know
- Cleared by the kidneys, so lower doses in kidney disease. In blood pressure trials it protected against stroke and death less well than other blood pressure medicines, so it’s rarely a first choice now
- Non-selectivePropranolol (Deralin, Inderal)
- Type
- Non-selective; gets into the brain
- Main uses
- Migraine prevention, tremor, the physical side of performance anxiety (off-label), symptoms of an overactive thyroid
- Good to know
- More likely to trigger wheeze. Usually taken 2 or 3 times a day. More dangerous in overdose than other beta blockers
- Non-selective plus vessel-wideningCarvedilol (Dilatrend)
- Type
- Non-selective, and also blocks alpha-1 receptors, which widens blood vessels
- Main uses
- Heart failure, blood pressure
- Good to know
- Twice a day with food. Dizziness on standing is more common when starting
- Very heart-selective plus vessel-wideningNebivolol (Nebilet)
- Type
- Very heart-selective at usual doses; also relaxes blood vessels (via nitric oxide)
- Main uses
- Blood pressure; heart failure in people aged 70 and over
- Good to know
- Once a day
- Rhythm specialistSotalol (Sotacor)
- Type
- Non-selective, plus a second rhythm-control action
- Main uses
- Keeping a normal rhythm in atrial fibrillation; some dangerous ventricular rhythms
- Good to know
- Can lengthen the QT interval on the ECG and trigger a dangerous rhythm (torsades de pointes). Started with ECG checks, dosed by kidney function, and low potassium or magnesium and some other medicines add to the risk
Side effects
Full side-effect list (from the product information)
How often, from the official product information (e.g. metoprolol). Bold = serious.
Very common more than 1 in 10
- Tiredness
- Drop in blood pressure, incl. on standing, sometimes with fainting
Common 1 in 10 to 1 in 100
- Dizziness or headache
- Slow heart rate
- Palpitations
- Cold hands and feet
- Short of breath on exertion
- Nausea, tummy pain, diarrhoea or constipation
Uncommon 1 in 100 to 1 in 1,000
- Low mood, poor concentration, nightmares
- Sleepiness or poor sleep, weight gain, pins and needles
- Worsening heart failure, heart block
- Chest pain
- Wheeze or asthma attack (bronchospasm)
- Vomiting, rash, sweating, cramps or swelling
Rare 1 in 1,000 to 1 in 10,000
- Nervousness, anxiety
- Vision changes, dry or sore eyes
- Heart rhythm disturbances
- Runny nose, dry mouth, hair loss
- Abnormal liver tests
- Unmasking of diabetes, sexual problems
Very rare fewer than 1 in 10,000
- Low platelets or white cells
- Memory problems, confusion or hallucinations
- Ringing in the ears, hearing problems
- Worse leg pain on walking or Raynaud’s
- Taste change, hepatitis, psoriasis flare
- Sun sensitivity, joint pain, weakness
Get help urgently if
- Wheeze or trouble breathing
- Fainting, a very slow pulse or chest pain
- Worsening breathlessness, swollen ankles or rapid weight gain
Good to know
- Don’t stop suddenly. This can trigger angina or a heart attack. Doses are reduced over 1 to 2 weeks.
- Usually avoided in asthma; used with care in COPD.
- Can hide signs of low blood sugar in diabetes. Verapamil and diltiazem add to the slowing.
- Some are used in pregnancy (e.g. labetalol). Discuss with your doctor.
Common questions
Are beta blockers used for anxiety?
Propranolol is sometimes used for the shaky, racing-heart side of performance anxiety, which is an off-label use. Beta blockers are mainly used for heart conditions, blood pressure, migraine prevention and tremor.
Can I stop beta blockers suddenly?
No. Stopping suddenly can trigger angina or a heart attack. Doses are reduced over 1 to 2 weeks.
Can I take beta blockers if I have asthma?
They are usually avoided in asthma and used with care in COPD. Get help urgently for wheeze or trouble breathing.
What are the names of common beta blockers?
Common ones include metoprolol, bisoprolol, atenolol, propranolol, carvedilol, nebivolol, sotalol and labetalol. Every generic name ends in “-lol”.
Information only. Not a recommendation or endorsement of any product. Whether a medicine suits you depends on your health and other medicines, so talk to your doctor or pharmacist. In an emergency, call 000 (Australia) or your local emergency number. From a mobile, 112 works in most countries.
More information
- Metoprolol tartrate 50 mg tablets summary of product characteristics (UK)
- Healthdirect: Medicines information
- Cochrane: Propranolol for migraine prevention
- CIBIS-II trial: Bisoprolol in heart failure (summary)
- Atenolol in hypertension: is it a wise choice? (The Lancet, 2004)
- Australian Prescriber: Nebivolol
- Australian Prescriber: Bisoprolol
maladywise.com/medicines/beta-blockers/